A series of car and suicide bombings has hit two government strongholds on Syria's Mediterranean coast.
State media said at least 78 people were killed, while a monitoring group put the death toll at more than 145.
Four bombings targeted bus stations in the port city of Tartous and in Jableh, a town to the north, which have until now escaped the worst of the civil war.
A news agency linked to so-called Islamic State (IS) said the jihadist group was behind the attacks.
Amaq cited an IS source as saying militants had targeted "gatherings of Alawites", a reference to the heterodox Shia sect to which President Bashar al-Assad belongs.
Russia - a key backer of Mr Assad - has a naval base in Tartous and an airbase near Jableh, from where it has conducted air strikes on IS targets across Syria.
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The state news agency, Sana, cited a police source as saying that 45 people were killed and many others, most of them women and children, were injured in Jableh.
It reported that two bombs exploded at the main entrance of the town's bus station.
A suicide bomber also blew himself up at the entrance of the emergency department at Jableh National Hospital, it added.
A suicide bomber also blew himself up at the entrance of the emergency department at Jableh National Hospital, it added.
A doctor at the hospital said it was bombed less than a minute after the bus station.
"Everything went into emergency mode, wounded people began arriving," Younes Hassan told the Reuters news agency.
The fourth blast reportedly occurred near the offices of Jableh's electricity directorate, on the outskirts of the Amara residential district.
In Tartous, more than 33 people were killed and 47 injured, Sana said.
A car bomb was detonated at the main gate to the city's bus station, while a suicide bomber detonated an explosive vest inside the facility, it added.
Bus driver Nizar Hamade told Reuters that the blasts occurred no more than 10 seconds apart.
"People began running but didn't know which direction to go, cars were on fire, there was blood and bodies on the ground," he added.
Another suicide bomber blew himself up in a western residential area of Tartous, Sana reported.
The Syrian Observatory for Human Rights, a UK-based monitoring group which relies on a network of sources on the ground, reported that 97 people were killed in Jableh and another 48 in Tartous.
The Syrian Observatory for Human Rights, a UK-based monitoring group which relies on a network of sources on the ground, reported that 97 people were killed in Jableh and another 48 in Tartous.
It also said the two bombings at the bus station in Jableh were suicide attacks.
Information Minister Omran al-Zoubi said terrorist groups were resorting to bomb attacks against civilians because they were unable to fight the Syrian army.
"We will not be deterred," he told al-Ikhbariya TV. "We will use everything we have to fight the terrorists."
Russia expressed concern at the blasts and said they underscored the need to revive the UN-led peace talks between the government and opposition, which broke down last month amid mounting violence.
Russia expressed concern at the blasts and said they underscored the need to revive the UN-led peace talks between the government and opposition, which broke down last month amid mounting violence.
"Of course a rise in tension and terrorist activity cannot but heighten concern. It is further proof of how fragile the situation is in Syria and demonstrates the necessity to continue active steps towards resuming talks," Kremlin spokesman Dmitry Peskov told reporters in Moscow.
President Vladimir Putin later sent his condolences to Mr Assad and reiterated his readiness to help the Syrian government combat "the terrorist threat".
IS, which controls large parts of northern and eastern Syria, carried out suicide bombings in the capital Damascus and the western city of Homs earlier this year.
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